Sparteine in PCCP

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Sparteine in PCCP

The dimer sparteine-water has been published in PCCP. Sparteine is a tetracyclic quinilizidine alkaloid used in assymetric synthesis, with two trans and cis conformations. We investigated whether addition of a water molecule flips the molecule by formation of a double hydrogen bond to the cis diamine. However, kinetic reasons explain that the cluster retains the monomer trans conformation.

In the picture below the conversion between the observed trans isomer (above) and the alternative cis isomer (below).